Essential —SH Groups in Liver Ketohexokinase
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چکیده
منابع مشابه
Effects of N-tricyanovinylamines on oxidative phosphorylation and level of SH-groups in rat liver mitochondria.
The effects of N-substituted tricyanovinylamines on oxidative phosphorylation as well as on glutathione and total SH group concentrations in rat liver mitochondria was studied. The N-TCVA derivatives studied (N-cyclohexyl; N-isobutyl; N-benzyl; N-phenyl; N-4-Br-phenyl; N-3-nitrophenyl) had an uncoupling effection on the oxidative phosphorylation. They stimulated the respiration of mitochondria ...
متن کاملThe purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol.
Ketohexokinase (EC 2.7.1.3) was purified to homogeneity from human liver, and fructose-bisphosphate aldolase (EC 4.1.2.13) was partially purified from the same source. Ketohexokinase was shown, by column chromatography and polyacrylamide-gel electrophoresis, to be a dimer of Mr 75000. Inhibition studies with p-chloromercuribenzoate and N-ethylmaleimide indicate that ketohexokinase contains thio...
متن کاملNeutrophil antigen (FcgammaRIIIB) SH gene frequencies in six racial groups.
Human leukocyte surface receptors specific for the Fc portion of IgG play a critical role in immune function by coupling the humoral and cellular immune systems. The Fcg receptor III (FcRIII) (CD 16), one of three Fc receptor classes, is encoded by two highly homologous genes on chromosome 1.1 FcRIIIA encodes the transmembrane receptor expressed on macrophages and natural killer cells and is no...
متن کاملRelationship between inhibition of membrane SH groups and hemolysis induced by SH inhibitors.
Many investigators have suggested that sulfhydryl (SH) groups may be essential for the maintenance of the integrity of mammalian erythrocytes (1-4). This conclusion was drawn after observing the hemolytic effects of such heavy metals as mercurials and such oxidants as oxygen or iodine on erythrocytes. In hemolytic anemia in man, a relationship between hemolysis and a deficiency of reduced gluta...
متن کاملitated proteins to avoid the rapid oxidation of SH groups
(14 ), which takes place after neutral pH is restored for the DTT reduction and mBBr conjugation. Measured basal GSSPs in human and rat RBCs are very low, and only a few previous reports found relatively close values (23 ). Conversely, most authors reported higher concentrations; one reason for these discrepancies could be that samples were frozen before the ESI-MS determination. It is possible...
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ژورنال
عنوان ژورنال: Nature
سال: 1963
ISSN: 0028-0836,1476-4687
DOI: 10.1038/197696a0